AVN-322 | 5-HT6 antagonist | Probechem Biochemicals

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Chemical Structure : AVN-322

AVN-322 (AVN322)

Catalog No.: PC-61502Not For Human Use, Lab Use Only.

AVN-322 is a highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AVN-322 is a highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.
AVN-322 significantly restores both scopolamine- and MK-801-induced cognitive dysfunction and demonstrates antipsychotic potential.

Physicochemical Properties

M.Wt	393.89
Formula	C17H20ClN5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N,7-dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-2-amine hydrochloride

References

1. Ivachtchenko AV, et al. Curr Alzheimer Res. 2017;14(3):268-294.

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AVN-322 (AVN322)

Biological Activity

Physicochemical Properties

References

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