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AVN-322 free base

Chemical Structure : AVN-322 free base

CAS No.: 1194574-33-8

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AVN-322 free base (AVN323 free base)

Catalog No.: PC-61503Not For Human Use, Lab Use Only.

AVN-322 free base is a highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AVN-322 free base is a highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.
    AVN-322 significantly restores both scopolamine- and MK-801-induced cognitive dysfunction and demonstrates antipsychotic potential.

    Physicochemical Properties

    M.Wt 357.432
    Formula C17H19N5O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N,7-dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-2-amine

    References

    1. Ivachtchenko AV, et al. Curr Alzheimer Res. 2017;14(3):268-294.

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