Chemical Structure : AVN-492
CAS No.:
1220646-23-0
AVN-492
(AVN492)
Catalog No.: PC-73302Not For Human Use, Lab Use Only.
AVN-492 is a highly potent and selective 5-HT6 receptor antagonist with Ki of 91 pM, >1000-fold selectivity over 5-HT2BR (Ki=170 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AVN-492 is a highly potent and selective 5-HT6 receptor antagonist with Ki of 91 pM, >1000-fold selectivity over 5-HT2BR (Ki=170 nM).
AVN-492 displays great 5-HT6R selectivity against all other serotonin receptor subtypes, and is extremely specific against any other receptors such as adrenergic, GABAergic, dopaminergic, histaminergic, etc.
AVN-492 demonstrates good in vitro and in vivo ADME profile with high oral bioavailability and good brain permeability in rodents.
AVN-492 shows anxiolytic effect in elevated plus-maze model, prevents an apomorphine-induced disruption of startle pre-pulse inhibition (the PPI model) and reverses a scopolamine- and MK-801-induced memory deficit in passive avoidance model.
Physicochemical Properties
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M.Wt
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359.448
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Formula
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C17H21N5O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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References
1. Ivachtchenko AV, et al. J Alzheimers Dis. 2017;58(4):1043-1063.
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