AW-814141 | p38 MAPK inhibitor | Probechem Biochemicals

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Chemical Structure : AW-814141

AW-814141 (AW814141)

Catalog No.: PC-63000Not For Human Use, Lab Use Only.

AW-814141 (AW814141) is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AW-814141 (AW814141) is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β.
AW-814141 inhibits the release of TNF-alpha by lipopolysaccharide (LPS) treated human peripheral blood mononuclear cells with IC50 of 212 nM.
AW-814141 inhibits paw swelling in CIA models.

Physicochemical Properties

M.Wt	375.476
Formula	C22H25N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(hexahydrocyclopenta(c)pyrrol-2-ylamino)-8-methyl-6-o-tolyl-8H-pyrido(2,3-d)pyrimidine-7-one

References

1. Chopra P, et al. Int Immunopharmacol. 2010 Apr;10(4):467-73.

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AW-814141 (AW814141)

Biological Activity

Physicochemical Properties

References

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