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Chemical Structure : AW-814141
Catalog No.: PC-63000Not For Human Use, Lab Use Only.
AW-814141 (AW814141) is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β.
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AW-814141 (AW814141) is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β.
AW-814141 inhibits the release of TNF-alpha by lipopolysaccharide (LPS) treated human peripheral blood mononuclear cells with IC50 of 212 nM.
AW-814141 inhibits paw swelling in CIA models.
| M.Wt | 375.476 | |
| Formula | C22H25N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chopra P, et al. Int Immunopharmacol. 2010 Apr;10(4):467-73.
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