AWD 12-281 | PDE4 inhibitor | Probechem Biochemicals

Chemical Structure : AWD 12-281

Catalog No.: PC-24966Not For Human Use, Lab Use Only.

AWD 12-281 (GW 842470) is a potent, orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 9.7 nM.

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Biological Activity

AWD 12-281 (GW 842470) is a potent, orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 9.7 nM.

M.Wt	458.27
Formula	C22H14Cl2FN3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,5-Dichloro-4-pyridyl)-2-[1-(4-fluorobenzyl)-5-hydroxy-3-indolyl]-2-oxoacetamide

1. Draheim R, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):555-63.

2. Bäumer W, et al. Eur J Pharmacol. 2002 Jun 20;446(1-3):195-200.