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AX-024

Chemical Structure : AX-024

CAS No.: 1370544-73-2

AX-024 (AX 024, AX024)

Catalog No.: PC-60400Not For Human Use, Lab Use Only.

AX-024 (AX024) is a first-in-class, specific inhibitor of T cell receptor (TCR), specifically inhibits TCR-Nck (SH3.1) interaction and TCR-dependent T cell activation (IC50=1 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AX-024 (AX024) is a first-in-class, specific inhibitor of T cell receptor (TCR), specifically inhibits TCR-Nck (SH3.1) interaction and TCR-dependent T cell activation (IC50=1 nM).
AX-024 does not inhibit BCR-triggered B cell proliferation mediated by the SH2 domain of Nck.
AX-024 inhibits the recruitment of endogenous Nck to CD3e, and therefore to the TCR.
Oral administration of AX-024 prevents the development of neurological symptoms in a model of multiple sclerosis (MS).
AX-024 exerts a long-lasting therapeutic effect in the EAE model of MS.

Physicochemical Properties

M.Wt 339.41
Formula C21H22FNO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine

References

1. Borroto A, et al. Sci Transl Med. 2016 Dec 21;8(370):370ra184.

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