Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Immunology/Inflammation-T Cell Receptor (TCR)-AX-024
AX-024

Chemical Structure : AX-024

CAS No.: 1370544-73-2

Add to Favorites

AX-024 (AX 024, AX024)

Catalog No.: PC-60400Not For Human Use, Lab Use Only.

AX-024 (AX024) is a first-in-class, specific inhibitor of T cell receptor (TCR), specifically inhibits TCR-Nck (SH3.1) interaction and TCR-dependent T cell activation (IC50=1 nM).

Packing Price Stock Quantity
5 mg $98 In stock
10 mg $148 In stock
50 mg $378 In stock
100 mg $558 In stock
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AX-024 (AX024) is a first-in-class, specific inhibitor of T cell receptor (TCR), specifically inhibits TCR-Nck (SH3.1) interaction and TCR-dependent T cell activation (IC50=1 nM).
AX-024 does not inhibit BCR-triggered B cell proliferation mediated by the SH2 domain of Nck.
AX-024 inhibits the recruitment of endogenous Nck to CD3e, and therefore to the TCR.
Oral administration of AX-024 prevents the development of neurological symptoms in a model of multiple sclerosis (MS).
AX-024 exerts a long-lasting therapeutic effect in the EAE model of MS.

Physicochemical Properties

M.Wt 339.41
Formula C21H22FNO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine

References

1. Borroto A, et al. Sci Transl Med. 2016 Dec 21;8(370):370ra184.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: