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Chemical Structure : AX-024 hydrochloride
CAS No.: 1704801-24-0
Catalog No.: PC-60401Not For Human Use, Lab Use Only.
AX-024 hydrochloride is a potent, orally available inhibitor of TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with IC50 of 1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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AX-024 hydrochloride is a potent, orally available inhibitor of TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with IC50 of 1 nM.
AX-024 hydrochloride inhibits phosphorylation of ZAP70 at Tyr319 and of CD3ζ at Tyr142.
AX-024 hydrochloride inhibits TCR triggering-induced gene expression (1093 genes), including genes that are relevant for inflammatory T cell responses (cytokines IL-17A, IL-2, IL-6R and IL-18R1).
AX-024 hydrochloride attenuates the severity of skin inflammation in a psoriasis model as well as of lung inflammation in an asthma model.
| M.Wt | 375.868 | |
| Formula | C21H23ClFNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-((4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride |
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1. Borroto A, et al. Sci Transl Med. 2016 Dec 21;8(370):370ra184.
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