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Chemical Structure : AXT107
CAS No.: 2417491-82-6
Catalog No.: PC-72429Not For Human Use, Lab Use Only.
AXT107 (Gersizangitide) is a mimetic peptide derived from collagen IV, binds integrins αvβ3 and α5β1 (Kd=1.29 and 2.21 nM), disrupts VEGFR2-β3 complex formation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
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| 100 mg | Get quote |
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AXT107 (Gersizangitide) is a mimetic peptide derived from collagen IV, binds integrins αvβ3 and α5β1 (Kd=1.29 and 2.21 nM), disrupts VEGFR2-β3 complex formation.
AXT107 inhibits VEGF-, HGF-, and PDGF-BB–stimulated phosphorylation of VEGFR2, c-Met, and PDGFRb receptors.
AXT107 also reduced total VEGFR2 levels by increasing internalization, ubiquitination, and degradation.
AXT107 suppressed subretinal neovascularization (NV) in two mouse models predictive of effects in neovascular age-related macular degeneration (NVAMD) and inhibited retinal NV in a model predictive of effects in ischemic retinopathies.
A combination of AXT107 and the current treatment aflibercept suppressed subretinal NV better than either agent alone.
AXT107 significantly reduced VEGF-induced vascular leakage by 86% at 1 month and 70% at 2 months in rabbit eyes, demonstrating the longer effectiveness than Aflibercept.
| M.Wt | 2355.69 | |
| Formula | C111H167N29O28 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in H2O |
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| Chemical Name/SMILES |
L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl- |
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1. Raquel Lima E Silva, et al. Sci Transl Med. 2017 Jan 18;9(373):eaai8030.
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