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AZ-27

Chemical Structure : AZ-27

CAS No.: 1516772-44-3

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AZ-27 (AZ27;AZ 27)

Catalog No.: PC-60359Not For Human Use, Lab Use Only.

AZ-27 (AZ27) is a potent non-nucleoside RSV L-protein polymerase inhibitor with EC50 of 0.01 uM and 1.3 uM for RSV A2 and RSV B-WST, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZ-27 (AZ27) is a potent non-nucleoside RSV L-protein polymerase inhibitor with EC50 of 0.01 uM and 1.3 uM for RSV A2 and RSV B-WST, respectively.
    AZ27 exhibits high potency against the RSV A subtype (average EC50=24±9 nM) than against the B subtype (average EC50=1.0±0.28 uM).
    AZ-27 (AZ27) shows no cytotoxicity.

    Physicochemical Properties

    M.Wt 633.767
    Formula C36H35N5O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(4-(2-(2-oxa-7-azaspiro[3.5]nonan-7-yl)nicotinamido)benzoyl)-N-cyclopropyl-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide

    References

    1. Tiong-Yip CL, et al. Antimicrob Agents Chemother. 2014 Jul;58(7):3867-73.

    2. Noton SL, et al. J Virol. 2015 Aug;89(15):7786-98.

    3. Deval J, et al. PLoS One. 2016 May 10;11(5):e0154097.

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