AZ-4217 | BACE1 inhibitor | Probechem Biochemicals

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Chemical Structure : AZ-4217

AZ-4217 (AZ4217)

Catalog No.: PC-63377Not For Human Use, Lab Use Only.

AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells.
AZ-4217 demonstrates excellent in vivo efficacy, lowers amyloid deposition in 12-month-old Tg2576 mice.

Physicochemical Properties

M.Wt	476.555
Formula	C30H25FN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-(3-amino-4-fluoro-1-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

References

1. Eketjäll S, et al. J Neurosci. 2013 Jun 12;33(24):10075-84.

2. Swahn BM, et al. J Med Chem. 2012 Nov 8;55(21):9346-61.

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AZ-4217 (AZ4217)

Biological Activity

Physicochemical Properties

References

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