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Chemical Structure : AZ-4217
Catalog No.: PC-63377Not For Human Use, Lab Use Only.
AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells.
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AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells; demonstrates excellent in vivo efficacy, lowers amyloid deposition in 12-month-old Tg2576 mice.
| M.Wt | 476.555 | |
| Formula | C30H25FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eketjäll S, et al. J Neurosci. 2013 Jun 12;33(24):10075-84.
2. Swahn BM, et al. J Med Chem. 2012 Nov 8;55(21):9346-61.
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