AZ-66 | Sigma receptor antagonist | Probechem Biochemicals

Chemical Structure : AZ-66

AZ-66 (AZ66)

Catalog No.: PC-21111Not For Human Use, Lab Use Only.

AZ-66 is a highly potent S1R/S2R antagonist with Ki of 0.31/1.76 nM, respectively.

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Biological Activity

AZ-66 is a highly potent S1R/S2R antagonist with Ki of 0.31/1.76 nM, respectively.
AZ-66 demonstrated anti-allodynic effects in the CCI assay.
AZ-66 exhibited antinociception with an ED50 value of 11.6 (8.29–15.6) mg/kg, i.p. against a thermal nociceptive stimulus in the mouse 55°C warm-water tail-withdrawal assay.

Physicochemical Properties

M.Wt	404.59
Formula	C23H33FN2OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(4-cyclohexylpiperidin-1-yl)pentyl)-6-fluorobenzo[d]thiazol-2(3H)-one

References

1. Cirino TJ, et al. Front Pharmacol. 2019 Jun 14;10:678.

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AZ-66 (AZ66)

Biological Activity

Physicochemical Properties

References

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