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Chemical Structure : AZ0108
Catalog No.: PC-62698Not For Human Use, Lab Use Only.
AZ0108 is an orally bioavailable phthalazinone PARP inhibitor with enzyme IC50 of <30/<30/83 nM for PARP1/2/6 respectively.
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AZ0108 is an orally bioavailable phthalazinone PARP inhibitor with enzyme IC50 of <30/<30/83 nM for PARP1/2/6 respectively.
AZ0108 displays >100-fold selectivity against PARP3/TNKS1/TNKS2 (IC50=2.8/3.2/>3 uM).
AZ0108 blocks centrosome clustering in HeLa cell with IC50 of 83 nM.
AZ0108 has been utilized as in vitro tool and in vivo probe to investigate the bio- logical consequences of inhibiting centrosome clustering through PARP enzymes.
| M.Wt | 500.458 | |
| Formula | 1825345-52-5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Johannes JW, et al. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5743-7.
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