AZ12204657 | GPR44 antagonist | Probechem Biochemicals

Chemical Structure : AZ12204657

AZ12204657 (AZ-12204657, AZ 12204657)

Catalog No.: PC-35910Not For Human Use, Lab Use Only.

AZ12204657 (AZ-12204657) small-molecule GPR44 antagonist, displaces the binding of [3H]PGD2 from membranes of HEK293 cells transfected with human recombinant GPR44 with IC50 of 2.5 nM.

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Biological Activity

AZ12204657 (AZ-12204657) is a small-molecule GPR44 antagonist, displaces the binding of [3H]PGD2 from membranes of HEK293 cells transfected with human recombinant GPR44 with IC50 of 2.5 nM.
[11C]AZ12204657 is a potential PET radioligand for the beta cell-restricted protein GPR44.

Physicochemical Properties

M.Wt	405.242
Formula	C16H14Cl2O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-chloro-2-(2-chloro-4-(methylsulfonyl)phenoxy)phenoxy)propanoic acid

References

1. Eriksson O, et al. Diabetes. 2018 Feb;67(2):182-192.

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AZ12204657 (AZ-12204657, AZ 12204657)

Biological Activity

Physicochemical Properties

References

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