Catalog No.: PC-49491Not For Human Use, Lab Use Only.
AZ1366 (AZ-1366) is a potent and selective inhibitor of TNSK1/2 with IC50 of 7 nM (TNKS1), also inhibits PARP1 with IC50 of 6 nM, shows Wnt pathway inhibition in DLD-1 cells (IC50<3 nM).
AZ1366 (AZ-1366) is a potent and selective inhibitor of TNSK1/2 with IC50 of 7 nM (TNKS1), also inhibits PARP1 with IC50 of 6 nM, shows Wnt pathway inhibition in DLD-1 cells (IC50<3 nM).
AZ1366 showed qualitatively stronger and longer lasting stabilization of Axin2, TNKS1, and TNKS2 at lower concentrations compared to XAV939 in DLD-1 cells.
AZ1366 synergistically suppresses NSCLC proliferation when combined with EGFR inhibitor gefitinib, exerts antiproliferative effects through inhibition of the canonical Wnt pathway.
AZ1366 inhibits basal and Wnt3a-activated β-catenin-dependent transcription in HCCC4006.
AZ1366 provided increased tumor control and improved survival in mice harboring Wnt-responsive tumors when combined with EGFR inhibitors.
