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AZ13711265

Chemical Structure : AZ13711265

CAS No.: 2016806-55-4

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AZ13711265 (AZ 13711265)

Catalog No.: PC-63151Not For Human Use, Lab Use Only.

AZ13711265 is a potent, selective, in vivo active PAK1 inhibitor with IC50 of 0.58 nM, displays 880-, 2100- and 90-fold selectivity over Src, FGFR1, KDR and PAK4.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZ13711265 is a potent, selective, in vivo active PAK1 inhibitor with IC50 of 0.58 nM, displays 880-, 2100- and 90-fold selectivity over Src, FGFR1, KDR and PAK4.
    AZ13711265 inhibits cellular pPAK1 inhibition in MCF10A cell line with IC50 of 110 nM.
    AZ13711265 is an in vivo probe compound with oral exposure in mouse.

    Physicochemical Properties

    M.Wt 554.685
    Formula C28H35FN6O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5-((2-((3-(ethylsulfonyl)-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)amino)-5-fluoropyrimidin-4-yl)(methyl)amino)-2,4-dimethylphenyl)methanol

    References

    1. McCoull W, et al. ACS Med Chem Lett. 2016 Sep 14;7(12):1118-1123.

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