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Chemical Structure : AZ14133346
Catalog No.: PC-22389Not For Human Use, Lab Use Only.
AZ14133346 is a potent and selective inhibitor of EGFR Ex20Ins with enzyme IC50 of <3 nM and cell IC50 of 85 nM, 14-fold selective over wild-type EGFR (cell IC50=1200 nM).
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AZ14133346 is a potent and selective inhibitor of EGFR Ex20Ins with enzyme IC50 of <3 nM and cell IC50 of 85 nM, 14-fold selective over wild-type EGFR (cell IC50=1200 nM).
AZ14133346 is both a potent and efficacious inhibitor of EGFR Ex20Ins and has an improved in vivo margin to WT when compared to CLN-081.
AZ14133346 can achieve robust Ex20Ins-mediated pathway inhibition in H2073 Ex20Ins SVD (D770_N771InsSVD) xenograft models.
| M.Wt | 477.57 | |
| Formula | C29H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Clare Thomson, et al. Journal of Medicinal Chemistry, May 21, 2024.
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