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AZ14145845

Chemical Structure : AZ14145845

CAS No.: 2830555-70-7

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AZ14145845 (Dual Axl-Mer inhibitor 32, AZ 14145845)

Catalog No.: PC-72617Not For Human Use, Lab Use Only.

AZ14145845 (Dual Axl-Mer inhibitor 32) is a potent, selective dual Axl/Mer inhibitor with pIC50 of 7.0/7.8.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZ14145845 (Dual Axl-Mer inhibitor 32) is a potent, selective dual Axl/Mer inhibitor with pIC50 of 7.0/7.8.
    AZ14145845 displays little to no inhibition against Flt-3, and Tyro3 (pIC50<4.5).
    AZ14145845 demonstrated dose-dependent in vivo efficacy and target engagement in Mer- and Axl-dependent efficacy models, also shows in vivo efficacy in a preclinical MC38 immuno-oncology model in combination with anti-PD1 antibodies and ionizing radiation.

    Physicochemical Properties

    M.Wt 561.694
    Formula C32H35N9O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((3-(4-((dimethylamino)methyl)phenyl)imidazo[1,2-a]pyridin-6-yl)methyl)-N-methyl-5-(3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridin-2-yl)-1,3,4-oxadiazol-2-amine

    References

    1. McCoull W, et al. J Med Chem. 2021 Sep 23;64(18):13524-13539.

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