AZ14240475

Chemical Structure : AZ14240475

Catalog No.: PC-23953Not For Human Use, Lab Use Only.

AZ14240475 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.6 in cellular SVD, (EGFR D770_N771insSVD) assays.

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Biological Activity

AZ14240475 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.6 in cellular SVD, (EGFR D770_N771insSVD) assays.

Physicochemical Properties

M.Wt	480.86
Formula	C23H15ClF2N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(5-((4-Chloropyridin-2-yl)oxy)-2,4-difluorophenyl)-1-(pyrimidin-4-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)prop-2-en-1-one

References

1. McCoull W, et al. J Med Chem. 2025 Jan 27. doi: 10.1021/acs.jmedchem.4c02811.

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AZ14240475

Biological Activity

Physicochemical Properties

References

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