AZ14245445

Chemical Structure : AZ14245445

Catalog No.: PC-23954Not For Human Use, Lab Use Only.

AZ14245445 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.9 in cellular SVD, (EGFR D770_N771insSVD) assays.

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Biological Activity

AZ14245445 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.9 in cellular SVD, (EGFR D770_N771insSVD) assays.

Physicochemical Properties

M.Wt	448.41
Formula	C23H15F3N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(4-(2,6-difluorophenyl)-5-fluoropyridin-2-yl)-1-(pyrimidin-4-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)prop-2-en-1-one

References

1. McCoull W, et al. J Med Chem. 2025 Jan 27. doi: 10.1021/acs.jmedchem.4c02811.

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AZ14245445

Biological Activity

Physicochemical Properties

References

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