AZ1495 | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : AZ1495

CAS No.: 2196204-23-4

AZ1495 (IRAK4 inhibitor 28)

Catalog No.: PC-60013Not For Human Use, Lab Use Only.

AZ1495 is a potent, selective IRAK4 inhibitor with IC50 of 51 nM.

Packing	Price	Stock
5 mg	$198	In stock
10 mg	$298	In stock
25 mg	$488	In stock
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Biological Activity

AZ1495 is a potent, selective IRAK4 inhibitor with IC50 of 51 nM.
AZ1495 demonstrates inhibition of NF-κB activation and growth of the ABC subtype of DLBCL cell lines in vitro in combination with ibrutinib.
AZ1495 shows tumor regression against mutant MYD88L265P DLBCL.

Physicochemical Properties

M.Wt	385.512
Formula	C21H31N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1r,4r)-4-morpholinocyclohexyl)-5-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

References

1. Scott JS, et al. J Med Chem. 2017 Dec 11. doi: 10.1021/acs.jmedchem.7b01290.

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AZ1495 (IRAK4 inhibitor 28)

Biological Activity

Physicochemical Properties

References

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