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AZ191

Chemical Structure : AZ191

CAS No.: 1594092-37-1

AZ191 (AZ-191)

Catalog No.: PC-42939Not For Human Use, Lab Use Only.

AZ191 is a potent, selective DYRK1B inhibitor with IC50 of 17 nM, displays 10-fold selectivity over DYRK1A and no activity against DYRK2 (IC50=1890 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ191 is a potent, selective DYRK1B inhibitor with IC50 of 17 nM, displays 10-fold selectivity over DYRK1A and no activity against DYRK2 (IC50=1890 nM).
AZ191 abolishes DYRK1B drives Thr(286) phosphorylation and proteasome-dependent turnover of CCND1 (cyclin D1) in HEK-293 and PANC-1 cells, but not by GSK3β inhibitors or GSK3β RNAi.

Physicochemical Properties

M.Wt 429.5175
Formula C24H27N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-

References

1. Ashford AL, et al. Biochem J. 2014 Jan 1;457(1):43-56.

2. Li Z, et al. Cancer Lett. 2016 Jan 28;370(2):332-44.

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