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Chemical Structure : AZ32
Catalog No.: PC-35077Not For Human Use, Lab Use Only.
AZ32 (ATM inhibitor AZ32) is a potent, selective, orally bioavailable, BBB-penetrating ATM inhibitor with IC50 of <6.2 nM, effectively blocks ATM auto-phosphorylation at S1981 with IC50 of 0.31 uM.
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AZ32 (ATM inhibitor AZ32) is a potent, selective, orally bioavailable, BBB-penetrating ATM inhibitor with IC50 of <6.2 nM, effectively blocks ATM auto-phosphorylation at S1981 with IC50 of 0.31 uM; shows radiosensitizing and DDR blocking ability in vitro in a panel of human glioma cell lines with different p53 status, including LN18, U1242, and T98G (all with mutant p53), as well as DBTRG and U87MG (with wild-type p53); AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models.
| M.Wt | 328.375 | |
| Formula | C20H16N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Karlin J, et al. Mol Cancer Ther. 2018 May 16. pii: molcanther.0975.2017.
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