Chemical Structure : AZ32
CAS No.:
AZ32
(AZ-32;ATM inhibitor AZ32)
Catalog No.: PC-35077Not For Human Use, Lab Use Only.
AZ32 (ATM inhibitor AZ32) is a potent, selective, orally bioavailable, BBB-penetrating ATM inhibitor with IC50 of <6.2 nM, effectively blocks ATM auto-phosphorylation at S1981 with IC50 of 0.31 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AZ32 (ATM inhibitor AZ32) is a potent, selective, orally bioavailable, BBB-penetrating ATM inhibitor with IC50 of <6.2 nM, effectively blocks ATM auto-phosphorylation at S1981 with IC50 of 0.31 uM; shows radiosensitizing and DDR blocking ability in vitro in a panel of human glioma cell lines with different p53 status, including LN18, U1242, and T98G (all with mutant p53), as well as DBTRG and U87MG (with wild-type p53); AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models.
Physicochemical Properties
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M.Wt
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328.375
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Formula
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C20H16N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-methyl-4-(6-phenylimidazo[1,2-a]pyrimidin-3-yl)benzamide
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References
1. Karlin J, et al. Mol Cancer Ther. 2018 May 16. pii: molcanther.0975.2017.
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