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Chemical Structure : AZ3976
CAS No.: 1418747-15-5
Catalog No.: PC-38547Not For Human Use, Lab Use Only.
AZ3976 is a small molecule inhibitor of plasminogen activator inhibitor type 1 (PAI-1) with IC50 of 26 uM in enzymatic chromogenic assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $178 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AZ3976 is a small molecule inhibitor of plasminogen activator inhibitor type 1 (PAI-1) with IC50 of 26 uM in enzymatic chromogenic assay.
AZ3976 binds to latent PAI-1 with Kd of 0.29 uM, does not bind to active PAI-1.
AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1.
| M.Wt | 317.349 | |
| Formula | C15H19N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
tert-butyl 3-((4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)azetidine-1-carboxylate |
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1. Fjellström O, et al. J Biol Chem. 2013 Jan 11;288(2):873-85.
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