AZ3976 | PAI-1 inhibitor | Probechem Biochemicals

Chemical Structure : AZ3976

CAS No.: 1418747-15-5

AZ3976 (AZ-3976)

Catalog No.: PC-38547Not For Human Use, Lab Use Only.

AZ3976 is a small molecule inhibitor of plasminogen activator inhibitor type 1 (PAI-1) with IC50 of 26 uM in enzymatic chromogenic assay.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
50 mg	$428	In stock
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Biological Activity

AZ3976 is a small molecule inhibitor of plasminogen activator inhibitor type 1 (PAI-1) with IC50 of 26 uM in enzymatic chromogenic assay.
AZ3976 binds to latent PAI-1 with Kd of 0.29 uM, does not bind to active PAI-1.
AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1.

Physicochemical Properties

M.Wt	317.349
Formula	C15H19N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl 3-((4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)azetidine-1-carboxylate

References

1. Fjellström O, et al. J Biol Chem. 2013 Jan 11;288(2):873-85.

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AZ3976 (AZ-3976)

Biological Activity

Physicochemical Properties

References

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