AZ 4800 |CAS:1226886-78-7 Probechem Biochemicals

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Chemical Structure : AZ 4800

AZ 4800 (AZ4800)

Catalog No.: PC-62920Not For Human Use, Lab Use Only.

AZ 4800 is a potent γ-secretase modulator that reduces Aβ40 and Aβ42 levels in HEK/APPswe cells with IC50 of 26 nM and 60 nM, also decreases Aβ39, whereas increases both Aβ37 and Aβ38..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ 4800 is a potent γ-secretase modulator that reduces Aβ40 and Aβ42 levels in HEK/APPswe cells with IC50 of 26 nM and 60 nM, also decreases Aβ39, whereas increases both Aβ37 and Aβ38.

Physicochemical Properties

M.Wt	435.528
Formula	C24H29N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(cyclopentyloxymethyl)-N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-amine

References

1. Borgegard T, et al. J Biol Chem. 2012 Apr 6;287(15):11810-9.

2. Strömberg K, et al. FEBS J. 2015 Jan;282(1):65-73.

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AZ 4800 (AZ4800)

Biological Activity

Physicochemical Properties

References

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