Catalog No.: PC-63158Not For Human Use, Lab Use Only.
AZ 5104 is the active metabolite of AZD 9291 (Osimertinib), which is an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC50=15-17 nM) that spares the wild-type form of the receptor (IC50=480 nM).
AZ 5104 is the active metabolite of AZD 9291 (Osimertinib), which is an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC50=15-17 nM) that spares the wild-type form of the receptor (IC50=480 nM).
AZ5104 inhibits cellular growth in Ex20Ins mutant cell lines in vitro and demonstrate sustained tumor growth inhibition of EGFR-mutant tumor xenograft harboring the most prevalent Ex20Ins in vivo.
