Catalog No.: PC-21961Not For Human Use, Lab Use Only.
AZ5385 is a small molecule EGFR inhibitor, also exhibits potent anti-HRV (human rhinovirus) activity with EC50 of 0.35 uM for HRV-2 in cell protection colorimetric assay, targeting the VP1 pocket of HRV.
AZ5385 is a small molecule EGFR inhibitor, also exhibits potent anti-HRV (human rhinovirus) activity with EC50 of 0.35 uM for HRV-2 in cell protection colorimetric assay, targeting the VP1 pocket of HRV.
AZ5385 is able to inhibit infection of cells by another HRV-A, i.e., HRV-16, and by RSV strain A2 but not by HRV-B type 14 (HRV-14), poliovirus type 1, SARS-2 coronavirus isolate DE-P3, and HSV-2 strain 333.
AZ5385 does not inhibit the pEGFR expression in cells but reduces the number of HRV-2-infected cells.
AZ5385 preferentially targets HRV progeny virions during their maturation in infected cells.
