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Chemical Structure : AZ5385
Catalog No.: PC-21961Not For Human Use, Lab Use Only.
AZ5385 is a small molecule EGFR inhibitor, also exhibits potent anti-HRV (human rhinovirus) activity with EC50 of 0.35 uM for HRV-2 in cell protection colorimetric assay, targeting the VP1 pocket of HRV.
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AZ5385 is a small molecule EGFR inhibitor, also exhibits potent anti-HRV (human rhinovirus) activity with EC50 of 0.35 uM for HRV-2 in cell protection colorimetric assay, targeting the VP1 pocket of HRV.
AZ5385 is able to inhibit infection of cells by another HRV-A, i.e., HRV-16, and by RSV strain A2 but not by HRV-B type 14 (HRV-14), poliovirus type 1, SARS-2 coronavirus isolate DE-P3, and HSV-2 strain 333.
AZ5385 does not inhibit the pEGFR expression in cells but reduces the number of HRV-2-infected cells.
AZ5385 preferentially targets HRV progeny virions during their maturation in infected cells.
| M.Wt | 460.89 | |
| Formula | C22H22ClFN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Masum Miah, et al. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0106423.
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