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AZ6102

Chemical Structure : AZ6102

CAS No.: 1645286-75-4

AZ6102 (AZ 6102;AZ-6102)

Catalog No.: PC-43304Not For Human Use, Lab Use Only.

AZ6102 is a potent, selective inhibitor of tankyrase TNKS1/2 with IC50 of 3/1 nM, displays >100-fold selectivity against other PARP family enzymes (PARP1/2/6).

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5 mg $78 In stock
10 mg $118 In stock
25 mg $198 In stock
50 mg $348 In stock
100 mg $548 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ6102 is a potent, selective inhibitor of tankyrase TNKS1/2 with IC50 of 3/1 nM, displays >100-fold selectivity against other PARP family enzymes (PARP1/2/6).
AZ6102 potently inhibits Wnt pathway in DLD-1 cells with IC50 of 5 nM.
AZ6102 AZ6102 is a probe compound to explore the in vivo effects of TNKS1/2 inhibition on normal tissue and tumor xenografts.

Physicochemical Properties

M.Wt 428.5294
Formula C25H28N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-,rel-

References

1. Johannes JW, et al. ACS Med Chem Lett. 2015 Jan 13;6(3):254-9.

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