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AZ9482

Chemical Structure : AZ9482

CAS No.: 1825345-33-2

AZ9482 (AZ 9482, AZ-9482)

Catalog No.: PC-62699Not For Human Use, Lab Use Only.

AZ9482 is a potent PARP inhibitor with IC50 of 1/1/46/9/160/640 nM for PAPR1/PARP2/PARP3/TNKS1/TNKS2/PAPR6 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ9482 is a potent PARP inhibitor with IC50 of 1/1/46/9/160/640 nM for PAPR1/PARP2/PARP3/TNKS1/TNKS2/PAPR6 respectively.
AZ9482 blocks centrosome clustering in HeLa cell with IC50 of <18 nM, shows activity in a Wnt pathway reporter assay, producing a DLD-1 firefly luciferase IC50 of 222 nM.
AZ9482 has been utilized as in vitro tool and in vivo probe to investigate the bio- logical consequences of inhibiting centrosome clustering through PARP enzymes.

Physicochemical Properties

M.Wt 450.502
Formula C26H22N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile

References

1. Johannes JW, et al. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5743-7.

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