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Chemical Structure : AZ9482
CAS No.: 1825345-33-2
Catalog No.: PC-62699Not For Human Use, Lab Use Only.
AZ9482 is a potent PARP inhibitor with IC50 of 1/1/46/9/160/640 nM for PAPR1/PARP2/PARP3/TNKS1/TNKS2/PAPR6 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | $898 | In stock | |
| 250 mg | Get quote |
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AZ9482 is a potent PARP inhibitor with IC50 of 1/1/46/9/160/640 nM for PAPR1/PARP2/PARP3/TNKS1/TNKS2/PAPR6 respectively.
AZ9482 blocks centrosome clustering in HeLa cell with IC50 of <18 nM, shows activity in a Wnt pathway reporter assay, producing a DLD-1 firefly luciferase IC50 of 222 nM.
AZ9482 has been utilized as in vitro tool and in vivo probe to investigate the bio- logical consequences of inhibiting centrosome clustering through PARP enzymes.
| M.Wt | 450.502 | |
| Formula | C26H22N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(4-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile |
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1. Johannes JW, et al. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5743-7.
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