Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Proton Pump-AZD-0865
AZD-0865

Chemical Structure : AZD-0865

CAS No.: 248919-64-4

AZD-0865 (Linaprazan;AZD0865;AZD 0865)

Catalog No.: PC-42143Not For Human Use, Lab Use Only.

A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5.

Packing Price Stock Quantity
5 mg $280 In stock
10 mg $400 In stock
50 mg $1200 In stock
100 mg $1680 In stock

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5; inhibits H+/K+-ATPase activity in a K(+)-competitive manner with Ki of 46 nM, shows no ativity for porcine renal Na(+),K(+)-ATPase at 100 uM; inhibits gastric acid secretion in vivo.

Ulcer

Phase 2 Discontinued

Physicochemical Properties

M.Wt 366.4567
Formula C21H26N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 35 mg/mL

Chemical Name/SMILES

Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(2,6-dimethylphenyl)methyl]amino]-N-(2-hydroxyethyl)-2,3-dimethyl-

References

1. Bailey N, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6.

2. Gedda K, et al. Biochem Pharmacol. 2007 Jan 15;73(2):198-205.

3. Kirchhoff P, et al. Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G838-43.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: