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Chemical Structure : AZD-3161
Catalog No.: PC-61854Not For Human Use, Lab Use Only.
AZD-3161 (AZD3161) is a potent and selective sodium channel Nav1.7 blocker with pIC50 of 7.1, >100-fold selective over NaV1.5.
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AZD-3161 (AZD3161) is a potent and selective sodium channel Nav1.7 blocker with pIC50 of 7.1, >100-fold selective over NaV1.5.
AZD-3161 shows high NaV1.7 potency and selectivity versus NaV1.5 and hERG, low lipophilicity, good solubility and high in vitro metabolic stability.
AZD-3161 shows in vivo efficacy in a nociceptive pain model.
| M.Wt | 459.56 | |
| Formula | C26H25N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bagal SK, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.
2. Kers I, et, al. Bioorg Med Chem Lett. 2012 Sep 1; 22(17): 5618-24.
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