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AZD-3161

Chemical Structure : AZD-3161

CAS No.: 1369501-46-1

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AZD-3161 (AZD3161)

Catalog No.: PC-61854Not For Human Use, Lab Use Only.

AZD-3161 (AZD3161) is a potent and selective sodium channel Nav1.7 blocker with pIC50 of 7.1, >100-fold selective over NaV1.5.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZD-3161 (AZD3161) is a potent and selective sodium channel Nav1.7 blocker with pIC50 of 7.1, >100-fold selective over NaV1.5.
    AZD-3161 shows high NaV1.7 potency and selectivity versus NaV1.5 and hERG, low lipophilicity, good solubility and high in vitro metabolic stability.
    AZD-3161 shows in vivo efficacy in a nociceptive pain model.

     

    Physicochemical Properties

    M.Wt 459.56
    Formula C26H25N3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((methylsulfonyl)amino)-2-phenyl-N-((1S)-1-phenylpropyl)-4-quinolinecarboxamide

    References

    1. Bagal SK, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.
    2. Kers I, et, al.  Bioorg Med Chem Lett. 2012 Sep 1; 22(17): 5618-24.

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