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Chemical Structure : AZD-7624
CAS No.: 1095004-78-6
Catalog No.: PC-63284Not For Human Use, Lab Use Only.
AZD-7624 (AZD7624) is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0, displays 15-fold selectivity for p38α over p38β MAPK and >10,000-fold selectivity over p38γ and p38δ MAPK.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $468 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AZD-7624 (AZD7624) is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0, displays 15-fold selectivity for p38α over p38β MAPK and >10,000-fold selectivity over p38γ and p38δ MAPK.
AZD-7624 inhibits LPS-induced TNF-α and IL-6 release in human alveolar macrophages pIC50 of 9.2 and 8.8, respectively。
AZD-7624 shows potential for prevention of exacerbations in COPD.
| M.Wt | 491.56 | |
| Formula | C27H30FN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-cyclopropyl-3-fluoro-4-methyl-5-(3-((1-(2-(2-(methylamino)ethoxy)phenyl)cyclopropyl)amino)-2-oxopyrazin-1(2H)-yl)benzamide |
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1. Patel NR, et al. Int J Chron Obstruct Pulmon Dis. 2018 Mar 27;13:1009-1019.
2. Pehrson R, et al. J Pharmacol Exp Ther. 2018 Mar 16. pii: jpet.117.246132.
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