Catalog No.: PC-44707Not For Human Use, Lab Use Only.
Osimertinib mesylate (AZD-9291) is a potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
Osimertinib shows weak activity against wt EGFR (IC50=184 nM).
Osimertinib mesylate (AZD-9291) is a potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
Osimertinib shows weak activity against wt EGFR (IC50=184 nM).
Osimertinib inhibits signaling pathways and cellular growth in both EGFRm(+) and EGFRm(+)/T790M(+) mutant cell lines in vitro.
Osimertinib exhibits tumor regression in EGFR-mutant tumor xenograft and transgenic models; orally active.
