Chemical Structure : AZD0156
CAS No.: 1821428-35-6
Catalog No.: PC-42030Not For Human Use, Lab Use Only.
AZD0156 (AZD-0156) is a potent, highly selective and orally bioavailable ATM kinase inhibitor with IC50 of 0.58 nM.
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AZD0156 (AZD-0156) is a potent, highly selective and orally bioavailable ATM kinase inhibitor with IC50 of 0.58 nM.
AZD0156 exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.
M.Wt | 461.556 | |
Formula | C26H31N5O3 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: 6.2 mg/mL (Need ultrasonic and warming) |
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Chemical Name/SMILES |
2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)- |
1. Degorce SL, et al. J Med Chem. 2016 Jul 14;59(13):6281-92.
2. Morgado-Palacin I, et al. Sci Signal. 2016 Sep 13;9(445):ra91.
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