AZD0186 | GLP-1R agonist | Probechem Biochemicals

Chemical Structure : AZD0186

AZD0186 (AZD-0186)

Catalog No.: PC-25613Not For Human Use, Lab Use Only.

AZD0186 is a potent, selective glucagon-like peptide-1 receptor (GLP-1R) agonist, shows concentration-dependent potentiation of GSIS in EndoC-βH5 cells with EC50 of 0.6 nM, improves glucose control and reduces body weight.

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Biological Activity

Physicochemical Properties

M.Wt	636.53
Formula	C32H31Cl2N5O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-2-(((1R,6R)-5-((S)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d][1,3]dioxol-4-yl)-2,5-diazabicyclo[4.2.0]octan-2-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid

References

1. Weier Qi, et al. J Pharmacol Exp Ther. 2025 Aug 28;392(10):103683.

2. Patent WO2023057427.

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AZD0186 (AZD-0186)

Biological Activity

Physicochemical Properties

References

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