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AZD0424

Chemical Structure : AZD0424

CAS No.: 692054-06-1

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AZD0424 (AZD-0424, AZD 0424)

Catalog No.: PC-62498Not For Human Use, Lab Use Only.

AZD 0424 is an orally bioavailable small molecule tyrosine kinase inhibitor of Abl and Src kinase with potential antineoplastic activity..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZD0424 is an orally bioavailable small molecule tyrosine kinase inhibitor of Abl and Src kinase, potently inhibits the phosphorylation of Tyr419 of SRC with IC50 of 100 nM in cancer cell lines.
    AZD0424 induces apoptosis and mediate cell cycle arrest in lymphoma cells.
    SRC is activated in response to treatment of KRAS-mutant colorectal cell lines with MEK inhibitors (trametinib or AZD6244) and that AZD0424 abrogates this.

    Physicochemical Properties

    M.Wt 528.994
    Formula C25H29ClN6O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-(2-((4-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)-5-isopropoxyquinazolin-7-yl)oxy)ethyl)piperazin-1-yl)ethan-1-one

    References

    1. Woodcock VK, et al. Br J Cancer. 2018 Feb 13. doi: 10.1038/bjc.2017.484.

    2. Nowak D, et al. Anticancer Drugs. 2007 Oct;18(9):981-95.

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