AZD1092 | Glucokinase activator | Probechem Biochemicals

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Chemical Structure : AZD1092

AZD1092 (GKA-80, AZ1092, GKA80)

Catalog No.: PC-61877Not For Human Use, Lab Use Only.

AZD1092 (GKA-80) is a potent Glucokinase (GK) activator with EC50 of 30 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD1092 (GKA-80) is a potent Glucokinase (GK) activator with EC50 of 30 nM.
AZD1092 exhibits dose dependent reduction of glucose excursion in oral glucose tolerance tests in high fat fed female Zucker rats.
AZD1092 shows potential for treatment of type 2 diabetes.

Physicochemical Properties

M.Wt	450.495
Formula	C24H26N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[4-(1-Azetidinylcarbonyl)phenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

References

1. Coope GJ, et al. Br J Pharmacol. 2006 Oct;149(3):328-35.

2. Michael J. Waring, et al. Med. Chem. Commun., 2011, 2, 775-779

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AZD1092 (GKA-80, AZ1092, GKA80)

Biological Activity

Physicochemical Properties

References

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