AZD1332 | Trk inhibitor | Probechem Biochemicals

Chemical Structure : AZD1332

AZD1332 (AZD-1332)

Catalog No.: PC-63149Not For Human Use, Lab Use Only.

AZD1332 is a potent, selective, ATP-competitive neurotrophic tyrosine kinase receptor (NRTK, TRK) inhibitor with IC50 of <10 nM.

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Biological Activity

AZD1332 is a potent, selective, ATP-competitive neurotrophic tyrosine kinase receptor (NRTK, TRK) inhibitor with IC50 of <10 nM.
AZD1332 inhibits phosphorylation of TrkA/B/C in MCF10A cells overexpressing TrkA and NIH3T3 cells over expressing TrkA, TrkB, or TrkC with IC50 of <5 nM.
AZD1332 inhibits a panel Baf3 survival driven by TrkA, TrkB, or TrkC with EC50 of 2 nM, AZD 1332 is orally available.

Physicochemical Properties

M.Wt	391.835
Formula	C17H19ClFN7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine

References

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AZD1332 (AZD-1332)

Biological Activity

Physicochemical Properties

References

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