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AZD1656

Chemical Structure : AZD1656

CAS No.: 919783-22-5

AZD1656 (AZD-1656)

Catalog No.: PC-49824Not For Human Use, Lab Use Only.

AZD1656 (AZD-1656) is a potent, selective and orally active glucokinase (GK) activator with EC50 of 57 and 72 nM for human and rat GK, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD1656 (AZD-1656) is a potent, selective and orally active glucokinase (GK) activator with EC50 of 57 and 72 nM for human and rat GK, respectively.
AZD1656 displays >100-fold versus hexokinase 1 and hexokinase2 in a pharmacology screening panel.
AZD1656 reduced plasma glucose levels in a dose-dependent fashion. with a rapid onset of action, in normo-glycaemic insulin resistant rats and diabetic mice.

Physicochemical Properties

M.Wt 478.51
Formula C24H26N6O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3-((5-(azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-((1-methoxypropan-2-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide

References

1. Norjavaara E, et al. J Clin Endocrinol Metab. 2012 Sep;97(9):3319-25.

2. Morrow LA, et al. Diabetes Obes Metab. 2012 Dec;14(12):1114-22.

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