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AZD1979

Chemical Structure : AZD1979

CAS No.: 1254035-84-1

AZD1979 (AZD-1979, AZD 1979)

Catalog No.: PC-61510Not For Human Use, Lab Use Only.

AZD1979 is a potent, selective melanin concentrating hormone receptor 1 (MCH-R1, MCHR1) antagonist with binding Ki of 12.2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD1979 is a potent, selective melanin concentrating hormone receptor 1 (MCH-R1, MCHR1) antagonist with binding Ki of 12.2 nM.
AZD1979 shows no apparent affinity for MCHR2 (Ki>40 uM).
AZD1979 dose-dependently reduces body weight in DIO mice leading to improved homeostasis model assessment-index of insulin sensitivity.

Physicochemical Properties

M.Wt 462.506
Formula C25H26N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

References

1. Johansson A, et al. J Med Chem. 2016 Mar 24;59(6):2497-511.

2. Ploj K, et al. Br J Pharmacol. 2016 Sep;173(18):2739-51.

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