Chemical Structure : AZD1979
CAS No.: 1254035-84-1
Catalog No.: PC-61510Not For Human Use, Lab Use Only.
AZD1979 is a potent, selective melanin concentrating hormone receptor 1 (MCH-R1, MCHR1) antagonist with binding Ki of 12.2 nM.
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AZD1979 is a potent, selective melanin concentrating hormone receptor 1 (MCH-R1, MCHR1) antagonist with binding Ki of 12.2 nM.
AZD1979 shows no apparent affinity for MCHR2 (Ki>40 uM).
AZD1979 dose-dependently reduces body weight in DIO mice leading to improved homeostasis model assessment-index of insulin sensitivity.
M.Wt | 462.506 | |
Formula | C25H26N4O5 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone |
1. Johansson A, et al. J Med Chem. 2016 Mar 24;59(6):2497-511.
2. Ploj K, et al. Br J Pharmacol. 2016 Sep;173(18):2739-51.
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