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Chemical Structure : AZD 3676
Catalog No.: PC-60738Not For Human Use, Lab Use Only.
A novel potent, combined serotonin 5-HT1A and 5-HT1B receptor antagonist with Ki of 0.13 and 2.4 nM in brain homogenates, respectively.
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A novel potent, combined serotonin 5-HT1A and 5-HT1B receptor antagonist with Ki of 0.13 and 2.4 nM in brain homogenates, respectively; shows preclinical properties consistent with CNS drug potential, including nanomolar receptor affinity and efficacy in rodent models of learning and memory, shows the potential for the treatment of cognitive impairment in Alzheimer's disease.
| M.Wt | 378.476 | |
| Formula | C22H26N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Varnäs K, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):464-71.
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