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Chemical Structure : AZD3676
Catalog No.: PC-60738Not For Human Use, Lab Use Only.
AZD3676 is a potent, combined serotonin 5-HT1A and 5-HT1B receptor antagonist with Ki of 0.13 and 2.4 nM in brain homogenates, respectively.
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AZD3676 is a potent, combined serotonin 5-HT1A and 5-HT1B receptor antagonist with Ki of 0.13 and 2.4 nM in brain homogenates, respectively.
AZD3676 shows preclinical properties consistent with CNS drug potential, including nanomolar receptor affinity and efficacy in rodent models of learning and memory, shows the potential for the treatment of cognitive impairment in Alzheimer's disease.
| M.Wt | 378.476 | |
| Formula | C22H26N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Varnäs K, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):464-71.
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