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AZD3676

Chemical Structure : AZD3676

CAS No.: 1259929-13-9

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AZD3676 (AZD 3676, AZD-3676)

Catalog No.: PC-60738Not For Human Use, Lab Use Only.

AZD3676 is a potent, combined serotonin 5-HT1A and 5-HT1B receptor antagonist with Ki of 0.13 and 2.4 nM in brain homogenates, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZD3676 is a potent, combined serotonin 5-HT1A and 5-HT1B receptor antagonist with Ki of 0.13 and 2.4 nM in brain homogenates, respectively.
    AZD3676 shows preclinical properties consistent with CNS drug potential, including nanomolar receptor affinity and efficacy in rodent models of learning and memory, shows the potential for the treatment of cognitive impairment in Alzheimer's disease.

    Physicochemical Properties

    M.Wt 378.476
    Formula C22H26N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N,N-dimethyl-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl) benzofuran-2-carboxamide

    References

    1. Varnäs K, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):464-71.

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