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Chemical Structure : AZD 4017
CAS No.: 1024033-43-9
Catalog No.: PC-61987Not For Human Use, Lab Use Only.
AZD4017 (AZD-4017) is a potent, selective, and orally bioavailable human 11β-HSD1 with IC50 of 7 nM, shows no significant activity against 11β-HSD1 and 17β-HSD1, 17β-HSD3 (IC50>30 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AZD4017 (AZD-4017) is a potent, selective, and orally bioavailable human 11β-HSD1 with IC50 of 7 nM, shows no significant activity against 11β-HSD1 and 17β-HSD1, 17β-HSD3 (IC50>30 uM).
AZD4017 is inactive (<25% inhibition at 10 μM) against Cytochrome P450 enzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4), and lower potency against the mouse, rat and dog 11β-HSD1 (IC50=750-4000 nM).
AZD4017 demonstrates the dose dependent inhibition of 11β-HSD1 in vivo.
| M.Wt | 419.58 | |
| Formula | C22H33N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid |
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1. Scott JS, et al. J Med Chem. 2012 Jun 28;55(12):5951-64.
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