AZD5991 (AZD-5991)

Chemical Structure : AZD5991

CAS No.: 2143061-81-6

Catalog No.: PC-61404Not For Human Use, Lab Use Only.

AZD5991 (AZD-5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity (SPR Kd=0.17 nM).

Packing	Price	Stock
5 mg	$198	In stock
10 mg	$298	In stock
25 mg	$488	In stock
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Biological Activity

AZD5991 (AZD-5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity (SPR Kd=0.17 nM).
AZD5991 promotes rapid apoptosis in Mcl-1-dependent cell lines (GI50=10 nM in multiple myeloma cell lines), disrupts Mcl-1/Bak complex.
AZD5991 completely causes tumor regression in several mouse xenograft models after a single tolerated dose.

Physicochemical Properties

M.Wt	672.259
Formula	C35H34ClN5O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aR)-5-Chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-22H-9,4,8-(metheniminomethyno)-14,20:26,23-dimetheno-10H,20H-pyrazolo[4,3-l][2,15,22,18,19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid

References

1. Alexander W. Hird, et al. Abstract DDT01-02: AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers, AACR. DOI: 10.1158/1538-7445.

AZD5991 (AZD-5991)

Biological Activity

Physicochemical Properties

References

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