AZD6482 |CAS:1173900-33-8 Probechem Biochemicals

Chemical Structure : AZD6482

CAS No.: 1173900-33-8

AZD6482 (AZD 6482;AZD-6482;KIN-193;KIN 193;KIN193)

Catalog No.: PC-42544Not For Human Use, Lab Use Only.

AZD6482 (KIN193) is a potent, selective and ATP competitive PI3Kβ inhibitor with IC50 of 10 nM.

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10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$378	In stock
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Biological Activity

AZD6482 (KIN193) is a potent, selective and ATP competitive PI3Kβ inhibitor with IC50 of 10 nM.
AZD6482 (KIN193) dispalys weak activity over PI3Kδ/PI3Kα/PI3Kγ/DNA-PK (IC50=80/870/1090/420 nM).
AZD6482 (KIN193) potently inhibits Akt(Ser 473) phosphorylation in adenocarcinoma MDA-MB-468 cells (IC50=40 nM).
AZD6482 (KIN193) inhibits insulin-induced human adipocyte glucose uptake in vitro (IC50=4.4 uM).

Physicochemical Properties

M.Wt	408.4503
Formula	C22H24N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]-

References

1. Giordanetto F, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3936-43.

2. Nylander S, et al. J Thromb Haemost. 2012 Oct;10(10):2127-36.

3. Laurent PA, et al. Blood. 2015 Jan 29;125(5):881-8.

AZD6482 (AZD 6482;AZD-6482;KIN-193;KIN 193;KIN193)

Biological Activity

Physicochemical Properties

References

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