AZD6738 (Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM.
AZD6738 (Ceralasertib) shows no significant activity for ATM, DNA-PK and mTOR.
AZD6738 (Ceralasertib) inhibits ATR kinase-dependent CHK1 phosphorylation in cells (IC50=74 nM).
AZD6738 (Ceralasertib) enhances the therapeutic efficacy of cisplatin in xenograft models。
AZD6738 (Ceralasertib) is orally active and bioavailable.
