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AZD7009

Chemical Structure : AZD7009

CAS No.: 864368-79-6

AZD7009 (AZD-7009)

Catalog No.: PC-63155Not For Human Use, Lab Use Only.

AZD7009 is an antiarrhythmic agent that inhibits the late sodium current in CHO K1 cells expressing hNav1.5 with IC50 of 11 uM.

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    Biological Activity

    AZD7009 is an antiarrhythmic agent that inhibits the late sodium current in CHO K1 cells expressing hNav1.5 with IC50 of 11 uM.
    AZD7009 also inhibits late sodium current in isolated rabbit atrial and ventricular myocytes, attenuates the E-4031-induced action potential duration prolongation, induces early afterdepolarisations (EADs) in Purkinje fibres.

    Physicochemical Properties

    M.Wt 446.548
    Formula C23H34N4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    tert-butyl N-[2-[3-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]nonan-7-yl]ethyl]carbamate

    References

    1. Goldstein RN, et al. J Cardiovasc Electrophysiol. 2004 Dec;15(12):1444-50.

    2. Persson F, et al. J Cardiovasc Electrophysiol. 2005 Mar;16(3):329-41.

    3. Persson F, et al. J Cardiovasc Pharmacol. 2005 Jul;46(1):7-17.

    4. Persson F, et al. Eur J Pharmacol. 2007 Mar 8;558(1-3):133-43.

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