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AZD 8329

Chemical Structure : AZD 8329

CAS No.: 1048668-70-7

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AZD 8329 (AZD8329)

Catalog No.: PC-62766Not For Human Use, Lab Use Only.

AZD8329 is a potent, selective 11β-HSD1 inhibitor with IC50 of 9 nM, displays excellent selectivity versus relatedd 11β-HSD2, 17β-HSD1 and 17β-HSD3 (IC50>30 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD8329 is a potent, selective 11β-HSD1 inhibitor with IC50 of 9 nM, displays excellent selectivity versus relatedd 11β-HSD2, 17β-HSD1 and 17β-HSD3 (IC50>30 uM).
AZD8329 shows significantly reduced acyl glucuronidation liability compared with AZD4017.

Physicochemical Properties

M.Wt 421.541
Formula C25H31N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid

References

1. Scott JS, et al. J Med Chem. 2012 Nov 26;55(22):10136-47.

2. Morentin Gutierrez P, et al. Br J Pharmacol. 2015 Oct;172(20):4806-16.

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