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Chemical Structure : AZD8683
Catalog No.: PC-61046Not For Human Use, Lab Use Only.
AZD8683 (AZD-8683) is a highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.
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AZD8683 (AZD-8683) is a highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.
AZD8683 reverses airflow obstruction by antagonizing para-sympathetic bronchoconstricting effects within the airways.
AZD8683 shows potential for chronic obstructive pulmonary disease (COPD) management.
| M.Wt | 542.518 | |
| Formula | C28H36BrN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mete A, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6248-53.
2. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174.
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