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AZD8683

Chemical Structure : AZD8683

CAS No.: 1194737-07-9

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AZD8683 (AZD-8683;AZD 8683)

Catalog No.: PC-61046Not For Human Use, Lab Use Only.

AZD8683 (AZD-8683) is a highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZD8683 (AZD-8683) is a highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.
    AZD8683 reverses airflow obstruction by antagonizing para-sympathetic bronchoconstricting effects within the airways.
    AZD8683 shows potential for chronic obstructive pulmonary disease (COPD) management.

    Physicochemical Properties

    M.Wt 542.518
    Formula C28H36BrN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-(2-oxo-2-(pyridin-2-ylamino)ethyl)-3-((1-phenylcycloheptane-1-carbonyl)oxy)quinuclidin-1-ium bromide

    References

    1. Mete A, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6248-53.

    2. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174.

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