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Chemical Structure : AZD8871
Catalog No.: PC-72979Not For Human Use, Lab Use Only.
AZD8871 (AZD-8871, Navafenterol) is a potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with pIC50 9.5 for human M3 receptor, pEC50 9.5 for β2-adrenoceptor.
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AZD8871 (AZD-8871, Navafenterol) is a potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with pIC50 9.5 for human M3 receptor, pEC50 9.5 for β2-adrenoceptor.
AZD8871 is selective for the β2-adrenoceptor over the β1 and β3 subtypes (3- and 6-fold, respectively) and shows dual antimuscarinic and β2-adrenoceptor functional activity in isolated guinea pig tissue (pIC50=8.6).
AZD8871 exhibits a higher muscarinic component than batefenterol in human bronchi, with a shift in potency under propranolol blockade of 2- and 6-fold, respectively.
AZD8871 prevents acetylcholine-induced bronchoconstriction in both guinea pig and dog with minimal effects on salivation and heart rate at doses with bronchoprotective activity.
| M.Wt | 742.91 | |
| Formula | C38H42N6O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Singh D, et al. Respir Res. 2020 Sep 9;21(Suppl 1):102.
2. Balaguer V, et al. Respir Res. 2020 Sep 9;21(Suppl 1):212.
3. Aparici M, et al. J Pharmacol Exp Ther. 2019 Jul;370(1):127-136.
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