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AZD9977

Chemical Structure : AZD9977

CAS No.: 1850385-64-6

AZD9977 (Balcinrenone, AZD-9977)

Catalog No.: PC-62592Not For Human Use, Lab Use Only.

Balcinrenone (AZD9977) is a novel, first-in-class, selective and oral mineralocorticoid receptor (MR) modulator with pKi of 7.5, shows little to no affitnity for GR, PR and AR (pIC50<5.5).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Balcinrenone (AZD9977) is a novel, first-in-class, selective and oral mineralocorticoid receptor (MR) modulator with pKi of 7.5, shows little to no affitnity for GR, PR and AR (pIC50<5.5).
Balcinrenone (AZD9977) dose dependently reduces albuminuria and improves kidney histopathology similar to eplerenone in db/db uni-nephrectomised mice and uni-nephrectomised rats, does not affect urinary Na+/K+ ratio.

Physicochemical Properties

M.Wt 399.378
Formula C20H18FN3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-(7-fluoro-4-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)-N-methylacetamide

References

1. Bamberg K, et al. PLoS One. 2018 Feb 23;13(2):e0193380.

2. Erlandsson F, et al. Br J Clin Pharmacol. 2018 Feb 21. doi: 10.1111/bcp.13562.

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