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Chemical Structure : AZD9977
CAS No.: 1850385-64-6
Catalog No.: PC-62592Not For Human Use, Lab Use Only.
Balcinrenone (AZD9977) is a novel, first-in-class, selective and oral mineralocorticoid receptor (MR) modulator with pKi of 7.5, shows little to no affitnity for GR, PR and AR (pIC50<5.5).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Balcinrenone (AZD9977) is a novel, first-in-class, selective and oral mineralocorticoid receptor (MR) modulator with pKi of 7.5, shows little to no affitnity for GR, PR and AR (pIC50<5.5).
Balcinrenone (AZD9977) dose dependently reduces albuminuria and improves kidney histopathology similar to eplerenone in db/db uni-nephrectomised mice and uni-nephrectomised rats, does not affect urinary Na+/K+ ratio.
| M.Wt | 399.378 | |
| Formula | C20H18FN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-(7-fluoro-4-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)-N-methylacetamide |
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1. Bamberg K, et al. PLoS One. 2018 Feb 23;13(2):e0193380.
2. Erlandsson F, et al. Br J Clin Pharmacol. 2018 Feb 21. doi: 10.1111/bcp.13562.
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