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Chemical Structure : AZ Dyrk1B 33
Catalog No.: PC-49263Not For Human Use, Lab Use Only.
AZ Dyrk1B 33 is a potent dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with IC50 of 16.8/39/254/430 nM for DYRK1A/1B/2/3, respectively, does not inhibit DYRK4 (IC50>30 uM).
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AZ Dyrk1B 33 is a potent dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with IC50 of 16.8/39/254/430 nM for DYRK1A/1B/2/3, respectively, does not inhibit DYRK4 (IC50>30 uM).
AZ Dyrk1B 33 decreased glucose levels in both larval and juvenile fish, recapitulated the effect on Tg(gip:nLuc) zebrafish at a lower concentration, also increased the number of K- and L-cells, did not change the number of beta-cells.
AZ Dyrk1B 33 promoted enteroendocrine cell differentiation through Nfatc4.
AZ Dyrk1B 33 (10 mg/kg, oral gavage) increases the prevalence of incretin+ cells and improved glucose control in diabetic mice.
| M.Wt | 300.365 | |
| Formula | C19H16N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lianhe Chu, et al. Cell Chem Biol. 2022 Aug 17;S2451-9456(22)00277-X.
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